The Alexandrian school is a collective designation for certain tendencies in literature, philosophy, medicine, and the sciences that developed in the Hellenistic cultural center of Alexandria, Egypt during the Hellenistic and Roman periods.

Alexandria was a remarkable center of learning due to the blending of Greek and Oriental influences, its favorable situation and commercial resources, and the enlightened energy of some of the Macedonian Dynasty of the Ptolemies ruling over Egypt, in the final centuries BC. Much scholarly work was collected in the great Library of Alexandria during this time. Large amounts of epic poetry and works on geography, history, mathematics, astronomy, philosophy, and medicine were composed in Alexandria during this period.

Alexandrian school is also used to describe the religious and philosophical developments in Alexandria after the 1st century. The mix of Jewish theology and Greek philosophy led to a syncretic mix and much mystical speculation. The Neoplatonists devoted themselves to examining the nature of the soul, and sought communion with God. The two great schools of biblical interpretation in the early Christian church incorporated Neoplatonism and philosophical beliefs from Plato's teachings into Christianity, and interpreted much of the Bible allegorically. The founders of the Alexandrian school of Christian theology were Clement of Alexandria and Origen.